Table 1.
Clinicopathological features of the OPSCC (oropharyngeal squamous cell carcinoma) patient cohort (n = 241 *).
| Risk Factors | All | HPV-Related | HPV-Negative | p | ||||
|---|---|---|---|---|---|---|---|---|
| (n = 241) | 100% | (n = 63) | 26% | (n = 177) | 74% | |||
| Nicotine | never | 44 | 18% | 24 | 39% | 20 | 11% | <0.001 |
| former/current | 195 | 82% | 38 | 61% | 156 | 89% | ||
| Alcohol | ≤ 2 drinks/day | 114 | 58% | 50 | 96% | 63 | 44% | <0.001 |
| > 2 drinks/day | 82 | 42% | 2 | 4% | 80 | 56% | ||
| Age | young (< 60 years) | 118 | 49% | 34 | 54% | 84 | 47% | 0.375 |
| old (≥ 60 years) | 123 | 51% | 29 | 46% | 93 | 53% | ||
| Gender | male | 189 | 78% | 44 | 70% | 144 | 81% | 0.057 |
| female | 52 | 22% | 19 | 30% | 33 | 19% | ||
| ECOG | healthy (0–1) | 172 | 74% | 45 | 78% | 127 | 72% | 0.417 |
| sick (2–4) | 62 | 26% | 13 | 22% | 49 | 28% | ||
| Tumor characteristics | ||||||||
| Localization | tonsil | 126 | 53% | 42 | 67% | 83 | 48% | 0.012 |
| other than tonsil | 110 | 47% | 21 | 33% | 89 | 52% | ||
| UICC7 stages | I−III | 98 | 41% | 24 | 38% | 74 | 42% | 0.562 |
| >III | 141 | 59% | 39 | 62% | 101 | 58% | ||
| T-stage | T1–3 | 190 | 79% | 54 | 86% | 135 | 77% | 0.149 |
| T> 3 | 49 | 21% | 9 | 14% | 40 | 23% | ||
| N-stage | N0 | 69 | 29% | 8 | 13% | 61 | 35% | 0.001 |
| N+ | 170 | 71% | 55 | 87% | 114 | 65% | ||
| M-stage | M0 | 222 | 95% | 60 | 98% | 161 | 94% | 0.296 a |
| M > 0 | 11 | 5% | 1 | 2% | 10 | 6% | ||
| Recurrence | no | 209 | 87% | 62 | 98% | 146 | 82% | <0.001 a |
| yes | 32 | 13% | 1 | 2% | 31 | 18% | ||
| Treatment | ||||||||
| Upfront Surgery | Yes | 175 | 73% | 54 | 86% | 120 | 68% | 0.006 |
| No | 66 | 27% | 9 | 14% | 57 | 32% | ||
p-values calculated by x² test (Pearson, asymptotic, two-sided) or a exact test (Fisher, two-sided), significant p-values (p ≤ 0.05) in bold; * 1 case with unknown human papillomavirus (HPV)-status.