. 2020 Dec 31;22(1):379. doi: 10.3390/ijms22010379

Table 3.

Univariate and multivariate survival analysis according to risk factors and tumor characteristics in the whole cohort (n = 241).

			Univariate											Multivariate
			Median Survival [Years]
		N	OS	CI		p	5Y-OS	HR	CI				p ^a	HR	CI		p ^a
All		N	OS	Lower	Upper	p	5Y-OS	HR	Lower		Upper		p ^a	HR	Lower	Upper	p ^a
LAG-3 Expression	no	166	4.822	3.657	5.768	0.036	51%						0.037				n.s.
LAG-3 Expression	yes	73	7.148	4.163	10.127	0.036	60%	0.668	0.456		0.976		0.037				n.s.
TIM-3 Expression	no	119	3.545	1.309	5.781	<0.001	45%						<0.001				n.s.
TIM-3 Expression	yes	122	7.551	n.a.	n.a.	<0.001	63%	0.515	0.364		0.729		<0.001				n.s.
VISTA Expression	no	73	3.129	0.489	5.768	0.049	45%						0.050				n.s.
VISTA Expression	yes	168	5.323	4.257	6.390	0.049	58%	0.707	0.500		1.000		0.050				n.s.
CD8 Expression	no	149	2.490	1.189	3.792	<0.001	40%	0.308		0.202		0.470	<0.001				<0.001
CD8 Expression	yes	89	n.a	n.a.	n.a.	<0.001	78%	0.308		0.202		0.470	<0.001	0.432	0.272	0.685	<0.001
HPV	HPV-negative	177	4.019	2.554	5.484	<0.001	44%						<0.001				0.003
HPV	HPV-related	63	n.a	n.a.	n.a.	<0.001	81%	0.276	0.161		0.472		<0.001	0.430	0.244	0.757	0.003
Age	young (<60 years)	118	8.600	5.445	11.755	0.001	63%						0.001				0.004
Age	old (≥60 years)	123	3.663	2.146	5.180	0.001	46%	1.794	1.297		2.517		0.001	1.663	1.171	2.362	0.004
ECOG	healthy (0–2)	172	6.608	4.272	8.944	<0.001	61%						<0.001				<0.001
ECOG	sick (3–4)	62	1.668	0.970	2.367	<0.001	31%	2.529	1.773		3.606		<0.001	2.377	1.626	3.475	<0.001
UICC 7 stages	1–3	98	6.655	3.659	9.650	0.017	63%						0.018				0.029
UICC 7 stages	≥4	141	4.181	2.053	6.309	0.017	48%	0.657	0.463		0.931		0.018	0.812	0.673	0.979	0.029

HR hazard ratios estimated by Cox proportional-hazards models; CI 95% confidence interval. p-values calculated by Log Rank (Mantel–Cox) test; univariate; p < 0.05 in bold; N/A: not applicable. ^a p-values estimated by Cox proportional-hazards models, uni- and multivariate; p < 0.05 in bold.