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. 2020 Dec 27;10(1):68. doi: 10.3390/jcm10010068

Table 5.

Pain outcomes.

Author Measurement Intra-Groups Between-Groups
Ferraz et al. [25] WOMAC pain sub scale. POST (% decrease)
BFR: 4.0 ± 2.9 (−39%); ES = −0.79
HI-RT: 4.6 ± 3.1 (−45%); ES = −0.59
LI-RT: 4.0 ± 2.6 (−31%); ES = −0.70
Segal et al. Women [28] KOOS (change pre-post)
BFR: 2.0 ± 2.8 0.2 ± 0.1
CG: 1.8 ± 2.7
Segal et al. Men [27] KOOS (change pre-post)
BFR: 5.6 ± 11.7 (4.9 ± 3.3%) 2.7 ± 1.7 (−9.3 ± −3.9)
CG: 2.9 ± 10.0 (14.2 ± 7.2%)
Bryk et al. [29] NPRS knee pain intensity Post
BFR: −3.3 ± 2.2 (−4.8, −1.7) −0.8 (2.2, 0.6)
CG: −2.5 ± 1.8 (−4.2, −0.8)
NPRS in exercise
BFR: 2.5 ± 1.5 −3.7 (−5.0, −2.4)
CG: 6.2 ± 2.2
Harper et al. [26] WOMAC pain sub scale.
CG decreased compared to BFR. 0.24 (−2.51, 2.98)
Hughes et al., 2018 [33] Muscular pain. Mean difference
a. BFR greater pain compared to healthy CG.
b. BFR greater pain compared to heavy-load CG.
c. Healthy greater pain compared to heavy-load CG.
a. 2.7 ± 1 (95% CI: 0.292–5.058)
b. 5 ± 1 (95% CI: 2.942–7.758)
c. 3 ± 1 (95% CI: 0.242–5.058)
Knee pain during session and at 24 h
BFR lower pain compared to heavy-load CG. 3 ± 1 (95% CI: 0.242–5.058)
Hughes 2019 [34] Muscular pain.
More pain with BFR
BFR: last session
Injured limb
Mean d = 0.5 (95% CI: 0.4–0.6) p < 0.05 *
Non- Injured limb Mean d = 1.0 (95% CI: 0.8–1.2)
CG: last session
Injured limb
Mean d = 0.8 (95% CI: 0.7–0.9)
Non-Injured limb Mean d = 0.7 (95% CI: 0.6–0.8)
Knee pain at 24 h.
Sessions average
Less pain with BFR Mean d = 3.1 (95% CI: 2.9–3.3)
BFR injured limb: average from all sessions Mean d = 2.9 (95% CI: 2.7–3.2)
CG injured limb: average from all sessions Mean d = 1.7 (95% CI: 1.3–2.0).
Knee pain during session
Less pain with BFR Mean d = 2.5 (95% CI: 2.2–2.8)
BFR injured limb: average from all sessions Mean d = 1.2 (95% CI: 0.7–1.4)
CG injured limb: average from all sessions Mean d = 0.6 (95% CI: 0.4–0.7)

Abbreviations: BFR, blood flow restriction; CG, control group; HI-RT, high-intensity resistance training; LI-RT, low-intensity resistance training; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index; KOOS, knee injury and osteoarthritis outcome Score; NPRS, numeric pain rating scale; ES, effect sizes; Sig., significant; CI, confidence interval; d, Cohen; *, numerical data not available.