Figure 1.

Statins induced a concentration−dependent inhibition of mitochondrial respiration in intact human platelets. (A) Representative traces of cerivastatin (red) and DMSO (grey) titration. Respiration of human platelets was measured after sub-maximal uncoupling with FCCP (2 µM). (B) The concentration-dependent effect of simvastatin (open square), atorvastatin (open circle) and cerivastatin (open triangle) was measured by titrating increasing concentrations of statin or vehicle (DMSO) (black rhombus). Data is expressed as mean±SEM. FCCP, carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone; DMSO, dimethyl sulfoxide; ROX, residual oxygen consumption. Two-way ANOVA with Bonferroni post hoc test was performed on antimycin-corrected data. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001 vs. DMSO.