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. 2021 Jan 3;22(1):424. doi: 10.3390/ijms22010424

Figure 3.

Figure 3

Statin effects on NADH−linked oxygen consumption in alamethicin-permeabilized platelet mitochondria. (A) Representative trace of simvastatin 160 µM (green) and DMSO (grey). (B) Oxygen consumption of permeabilized platelet mitochondria was measured at three points: Figure 0. mM) next in the presence of the statin (160 µM)/DMSO control (DMSO-grey bar, simvastatin-green bar, atorvastatin-blue bar, cerivastatin-red bar) and then after the addition of statin plus a second dose of NADH (0.75 mM). (C) Calculated NADH-linked oxygen consumption (∆) for each statin and DMSO control, evaluated as the ratio between the two consecutive additions of NADH (NADH2/NADH1). Data is expressed as mean ± SEM of rotenone-corrected data, one-way ANOVA with Bonferroni post hoc test. DMSO, dimethyl sulfoxide. ** p < 0.01; **** p < 0.001 vs. DMSO.