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. 2021 Jan 3;22(1):424. doi: 10.3390/ijms22010424

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effects of NV118 on statin−dependent respiratory dysfunction in human platelets. (A) Representative overlay trace of statin-exposed platelets in the absence (red) or presence (blue) of the succinate prodrug NV118. NV118 effects in cerivastatin (B1,C1,D1) and atorvastatin (B2,C2,D2) exposed platelets were measured as compared to its vehicle (DMSO). As negative control of the experiment, platelets were exposed only to DMSO (DMSO-DMSO). Data is expressed as mean±SEM. One-way ANOVA with Bonferroni post hoc test was performed on antimycin-corrected data. ATORVA, atorvastatin; CERI, cerivastatin; DMSO, dimethyl sulfoxide; ET, electron transport. ns = no significance; * p < 0.05; ** p < 0.01.