Figure 5.

The effects of NV118 on statin−dependent respiratory dysfunction in HepG2 cells. (A) Respiration was assessed after sub-maximal uncoupling with FCCP (4 µM) followed by increasing concentrations of atorvastatin or vehicle (DMSO). NV118 effects on atorvastatin exposed HepG2 cells (B–D) were measured as compared to its vehicle (DMSO). As negative control of the experiment HepG2 cells were exposed only to DMSO (DMSO-DMSO). Data is expressed as mean ± SEM. One-way ANOVA with Bonferroni post hoc test was performed on antimycin-corrected data. ATORVA, atorvastatin; DMSO, dimethyl sulfoxide; ET, electron transport. ns = no significance; * p < 0.05; ** p < 0.01; **** p < 0.0001.