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Production of 5-HTP from glucose in engineered E. coli by using a novel salicylate 5-hydroxylase. PEP, phosphoenol pyruvate; E4P, erythrose-4-phosphate; TrpEfbrG, anthranilate synthase (from a feedback resistance mutant); SalABCD, salicylate 5-hydroxylase; TrpDCA and TrpB, E. coli native tryptophan biosynthetic enzymes. Adapted from [90].
