Figure 10.

Summary of effects of 5-HTP on some animals. In terrestrial snails, 5-HTP reinstates the context memory, whereas in mice, 5-HTP produces a characteristic head twitch and tremors, induces hypoglycemia, and suppresses inflammation by inducing pro-inflammatory mediators. In rats, most of the listed effects of 5-HTP are dose dependent. In guinea pigs, 5-HTP enhances myoclonus and facilitates the luminal 5-HT release. In dogs, 5-HTP increases propulsive activity, contractive force, and mobility index. Injection of 5-HTP facilitates the stretch reflex in cats and produces a fall in temperature in rabbits. In sheep, 5-HTP increases serum melatonin and foetal breathing movements and stimulates an autocrine–paracrine adaptation to lactation in cows. Created with BioRender.com.