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. 2021 Jan 5;135(1):1–17. doi: 10.1042/CS20200482

Table 1. Overview of current clinical trials evaluating various therapeutic agents on COVID-19.

Clinical trial Identifier Title of the clinical trial Setting, severity Active arm(s) Status
NCT04364893 Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Patients With COVID-19 (BRACE-CORONA) Hospitalized, COVID-19 (∼700 subjects) ACEi and ARBs Recruiting
NCT04335136 Recombinant Human Angiotensin-converting Enzyme 2 (rhACE2) as a Treatment for Patients With COVID-19 (APN01-COVID-19) Hospitalized, COVID-19 (200 subjects) RhACE2, APN01 Recruiting
NCT04321096 The Impact of Camostat Mesilate on COVID-19 Infection (CamoCO-19) Hospitalized, COVID-19 (580 subjects) Camostat Mesilate Recruiting
NCT04338009 Elimination or Prolongation of ACE Inhibitors and ARB in Coronavirus Disease 2019 (REPLACECOVID) Hospitalized, COVID-19 (152 subjects) ARB/ACEi Recruiting
NCT04312009 Losartan for Patients With COVID-19 Requiring Hospitalization Hospitalized, COVID-19 (200 subjects) Losartan Recruiting
NCT04311177 Losartan for Patients With COVID-19 Not Requiring Hospitalization Patients with COVID-19 (580 subjects) Losartan Active, not Recruiting
NCT04318418 ACE Inhibitors, Angiotension II Type-I Receptor Blockers and Severity of COVID-19 (CODIV-ACE) Hospitalized, COVID-19 (3400 subjects) ACEi and ARBs Completed
NCT04315298 Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19 Hospitalized, COVID-19 (1912 subjects) Sarilumab Completed
NCT04320615 A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia (COVACTA) Hospitalized, severe COVID-19 Pneumonia (450 subjects) Tocilizumab (TCZ) Completed
NCT04330638 Treatment of COVID-19 Patients With Anti-interleukin Drugs (COV-AID) Hospitalized, CIVID-19 with systemic cytokine release syndrome (342 subjects) Anakinra Siltuximab Tocilizumab Recruiting
NCT04322188 An Observational study of the Use of Siltuximab (SYLVANT) in Patients Diagnosed With COVID-19 Infection Who Have Developed Serious Respiratory Complications (SISCO) Hospitalized, ARDS, secondary to SARS-COV-2 Infection (220 subjects) Siltuximab (SYLVANT) Completed