Table 2.
Molecular imaging by using amino acid transporters.
| Transporter | Tracer | Experimental Model | Tissue Type | References |
|---|---|---|---|---|
| SLC1A1 | N-(2-(18F)fluoropropionyl)-L-glutamate ((18F)FPGLU) | In vitro (Cell line) | Rat C6 glioma cell line, SPC-A-1 lung adenocarcinoma cell line | [213] |
| In vivo (Cell line derived-xenograft) | ||||
| SLC1A5 | 18F-Ala-BF3 | In vivo (Cell line derived-xenograft) | Gastric cancer cell line xenograft | [214] |
| SLC1A5 | 4-(18F)Fluoro-Gln | In vivo (Cell line derived-xenograft) | Non-Small Cell Lung Cancer and Colorectal Carcinoma xenografts | [215] |
| In vivo (EGFR-mutant Mouse model) | ||||
| SLC1A5, SLC7A5 | (18F)fluciclovine | In vitro (Cell line) | Castration-resistant prostate cancer | [216,217] |
| SLC3A2 | Anticalin | Primary prostate cancer tissue | Primary prostate cancer tissue | [218] |
| SLC7A5 | 2-(18F)FELP | In vitro (Cell line) | Glioblastoma [219,220] | [219,220] |
| In vivo (Cell line derived-xenograft) | ||||
| SLC7A5 | [18F]FET | In vitro (Cell line) | Glioblastoma [219,220,221] | [219,220,221] |
| In vivo (Cell line derived-xenograft) | ||||
| SLC7A5 | 18F-FIMP | In vivo (Cell line derived-xenograft) | Glioblastoma | [222] |
| SLC7A5 | 18F-FBPA | In vivo (Cell line derived-xenograft) | C6 Glioma and MIA PaCa-2 xenografts | [223] |
| SLC7A5 | 18F-FAMT | In vitro (Cell line) | C6 Glioma and MIA PaCa-2 xenografts [223], Xenopus oocytes [224] | [223,224] |
| In vivo (Cell line derived-xenograft) | ||||
| In vitro (Xenopus laevis oocytes) | ||||
| SLC7A5 | P(NIPAAm-co-DMAAm) | In vitro (Cell line) | Cervical carcinoma (HeLa cells) | [225] |
| SLC7A5 | (18F)-FDOPA | In vitro (Cell line) | Non tumoral brain tissues and brain metastases [226], Glioblastoma [227] | [226,227] |
| Brain tumor tissue |