Table 5.
Synergistic effect of O. campechianum EO employing fluconazole as synthetic active drug against Candida spp.
| FICindex MIC (EO + FLU) |
FICindex MFC (EO + FLU) |
EO MIC MFC |
FLU MIC MFC |
|||
|---|---|---|---|---|---|---|
| C. albicans (AIDS6) | 1.031 (1563 − 4) * |
1.031 (1563 − 4) * |
1563 | 1563 | 128 | 128 |
| C. glabrata (FLU 43976) | 0.562 (781 − 8) * |
0.562 (781 − 8) * |
1563 | 1563 | 128 | 128 |
| C. albicans (ATCC 24433) | 1.004 (3135 − 0.5) * |
1.004 (3135 − 0.5) * |
3135 | 3135 | 128 | 128 |
FICindex: fractional inhibitory concentration index; FICindex ≤ 0.5 means the presence of synergistic effect; 0.5 ≤ FICindex ≤ 2 means additive or indifferent effect; FICindex >2 means antagonistic effect [11,36].* Concentration in µg/mL of EO and FLU, respectively, corresponding to FICindex. MIC: Minimum Inhibitory Concentration (µg/mL); MFC: Minimum Fungicidal Concentration (µg/mL). EO: O. campechianum EO; FLU: fluconazole.