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. 2020 Dec 27;26(1):84. doi: 10.3390/molecules26010084

Table 5.

Synergistic effect of O. campechianum EO employing fluconazole as synthetic active drug against Candida spp.

FICindex MIC
(EO + FLU)
FICindex MFC
(EO + FLU)
EO
MIC MFC
FLU
MIC MFC
C. albicans (AIDS6) 1.031
(1563 − 4) *
1.031
(1563 − 4) *
1563 1563 128 128
C. glabrata (FLU 43976) 0.562
(781 − 8) *
0.562
(781 − 8) *
1563 1563 128 128
C. albicans (ATCC 24433) 1.004
(3135 − 0.5) *
1.004
(3135 − 0.5) *
3135 3135 128 128

FICindex: fractional inhibitory concentration index; FICindex ≤ 0.5 means the presence of synergistic effect; 0.5 ≤ FICindex ≤ 2 means additive or indifferent effect; FICindex >2 means antagonistic effect [11,36].* Concentration in µg/mL of EO and FLU, respectively, corresponding to FICindex. MIC: Minimum Inhibitory Concentration (µg/mL); MFC: Minimum Fungicidal Concentration (µg/mL). EO: O. campechianum EO; FLU: fluconazole.