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. 2021 Jan 4;14(1):208. doi: 10.3390/ma14010208

Figure 5.

Figure 5

Effect of tryptophan or kynurenine on bone regeneration in mice femur surgical defect. (A) Schema showing the study design. Mice were then administered the two amino acids for 2 more weeks. (B,D) Three-dimensional micro-CT images of mouse femur defects after intraperitoneal injection with PBS or L-Trp (50 mg/kg) or L-Kyn (50 mg/kg). The bone healing ability after three weeks of L-Trp or L-Kyn-treated group was accelerated compared to the respective PBS-injected control group. The analysis was performed with Skyscan software. The images are representative of four different samples. The white arrow indicates the defect. (C,E) Histological analysis of mouse femurs in the defect area. Note the amount of regenerated bone volume in L-Trp (C) and L-Kyn-treated (E) groups. Data represent the mean ± SD (n = 4). * p < 0.05, ** p < 0.01, unpaired t-test.