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. 2021 Jan 5;14(1):223. doi: 10.3390/ma14010223

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histological evaluation of sheep iliac defects at 2 months (a–c) and 4 months (d–f) with hematoxylin and eosin (HE) staining. (a) Cellular phagocytosis of PR-DDM (asterisk) by multinucleated giant cells (black arrows), (b) New bone induction (NB) with regular osteoblast layer (arrow) by PR-DDM (asterisk), (c) Well-demarcated boundary (arrow) observed between PR-DDM (asterisk) and new bone (NB); note: osteoblast layer (blue arrow) on new bone, (d) Cellular absorption of PR-DDM (asterisk) by the higher number of multinucleated giant cells (black arrows), (e) New bone (NB) with mosaic-like structure induced by PR-DDM, (f) Simultaneous evidence of new bone formation (NB) with osteoblasts (blue arrow) and PR-DDM bio-absorption (asterisk) by multinucleated giant cells (black arrows).