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. 2021 Jan 9;21:39. doi: 10.1186/s12884-020-03486-7

Table 3.

Neonatal outcomes among different infertility etiologies for IVF compared to spontaneous pregnancies in singleton pregnancies

Control Ovulation disorder Tubal disease Endometriosis Male infertility Mixed infertility
Singleton Pregnancies N % N % N % N % N % N %
6832 271 542 74 267 87
Gestational weeks 38.8±1.5 38.3±1.8* 38.5±1.6* 38.3±1.8^ 38.5±1.8^ 38.1±1.9*
Preterm birth 355 5.2 25 9.2^ 36 6.6 7 9.5 20 7.5 11 12.6^
34≤PTD<37 wk 267 3.9 17 6.3 29 5.4 5 6.8 16 6 9 10.3^
28≤PTD<34 wk 88 1.3 8 3^ 7 1.3 2 2.7 5 1.9 2 2.3
Birthweight, g( Mean±SD) 3370±474 3379±580 3382±498 3244±502^ 3335±519 3278±518
Birthweight centile(Mean±SD) 57.29±24.81 59.51±26.60 57.29±26.02 51.84±27.97 55.28±26.80 57.37±26.53
< 2500 g 236 3.5 17 6.3^ 21 3.9 4 5.4 13 4.9 6 6.9
< 1500 g 38 0.6 4 1.5 3 0.6 0 0 3 1.1 1 1.1
SGA 281 4.1 18 6.6^ 21 3.9 7 9.5^ 12 4.5 5 5.7
Macrosomia 521 7.6 31 11.4^ 64 11.8* 10 13.5 20 7.5 6 6.9
Body length, cm 50.55±41.78 49.85±2.37 50.02±1.88 49.73±2.01 49.92±2.04 49.63±2.12^
1-Minute Apgar score≤7 64 0.9 5 1.8 4 0.7 0 0 4 1.5 4 4.6*
5-Minute Apgar score≤7 10 0.1 1 0.4 3 0.6* 0 0 0 0 0 0
NICU admission 728 10.7 48 17.7* 72 13.3 17 23* 33 12.4 15 17.2^

Note: PTD preterm delivery, SGA small for gestational age( birthweight below the 10th percentile for gestational age); Macrosomia = birth weight ≥ 4000g

Mixed infertility refers to multiple infertility-related diagnosis

Data are presented as means±SDs for continuous variables and n (%) for dichotomous variables. P values were assessed by using the Pearson’s chi-square test, Fisher’s exact test or the t test between each infertility subgroup vs controls ; P ≤ 0.001 = *; P < 0.05 = ^. Nonsignificant numbers have not symbol