Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 9;11:13. doi: 10.1186/s13578-020-00522-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 9 — Role of Piezo1 in erythrocytes. The left side of the figure depicts the Piezo1 channel regulating erythrocyte volume. In overhydrated red blood cells (RBCs), Piezo1-mediated Ca²⁺ influx activates K⁺ efflux through the Gardos channel (KCa3.1), which in turn leads to water loss and RBC dehydration. The right side of the figure shows the working model for how Piezo1 channel activation regulates the release of ATP from erythrocytes. In erythrocytes, shear can activate the Piezo1 channel and induce Ca²⁺ influx, which triggers significant ATP release that is dependent on pannexin-1 (Px1)