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. Author manuscript; available in PMC: 2021 Jan 9.
Published in final edited form as: Org Biomol Chem. 2020 Sep 23;18(36):7110–7126. doi: 10.1039/d0ob01447h

Scheme 2.

Scheme 2

Asymmetric (left) and symmetric (right) conformations of the two cyclic octadepsipeptides PF1022A (1) and emodepside (2) consisting of four l-N-methyl leucines (Mle), two d-lactic acid moieties (d-Lac) and two d-phenyllactic acid moieties (d-Phl) (with additional morpholine rings in para position in case of 2 (d-Phm)). In the C2 symmetric conformation, the chemically equivalent residues share a common designation derived from their position in the asymmetric conformation.