Table 1.
Ratios between asymmetric and symmetric conformer in CD3OH and CDCl3 for compounds 1, 2 and 8. Literature values are given in parentheses. Ratio marked with * was reported in CD3OD
| Compound | Conformer ratio in CD3OH (asymmetric : symmetric) | Conformer ratio in CDCl3 (asymmetric : symmetric) |
|---|---|---|
| PF1022A (1) | 5 : 1–7 : 1a (4 : 1*9) | 3 : 1 (3 : 138) |
| Emodepside (2) | 7 : 1 | 7 : 2 |
| Bis-aza analog (8) | 12 : 1 | 10 : 1 (100 : 736) |
a
The variability is likely due to residual cation content originating from synthesis, workup and purification that differs from batch to batch.