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. 2021 Jan 9;12:53. doi: 10.1186/s13287-020-02121-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Gene expression changes in MSCs treated with IFNγ. a A mean difference plot showing DEGs identified in MSCs treated with IFNγ. b Representative genes upregulated in IFNγ-licensed MSCs. c Enrichment map showing pathways enriched in INFγ-treated MSCs (red) and untreated MSCs (blue). d Boxplot showing immunosuppressive scores for each group calculated based on VEGF, IFNa, CXCL10, GCSF, CXCL9, IL-7, and CCL2 expression level. e Results showing MSCs from ssG0, ssG2, and ssG4 co-cultured with PBMC for immunosuppressive potency assessment