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. 2021 Jan 9;14:20. doi: 10.1186/s13104-020-05426-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The effect of prone positioning on gas exchange and respiratory mechanics are shown in (a–c). a Line graph representing mean PaO2/FiO2 ratio before, during, and after prone positioning, n=20, b Line graph representing mean Aa gradient before, during, and after prone positioning, n = 20, (c) Line graph representing mean respiratory system static compliance (CRS) before, during, and after prone positioning, n = 15, (d) shows the association between respiratory system static compliance (CRS) and severity of SARS-CoV-2 ARDS. It displays a box plot representing the difference in baseline PF ratio between patients with <median CRS and > median CRS, n = 19. PF = PaO2/FiO2 ratio, Aa = Alveolar-arterial gradient, CRS = respiratory system static compliance. Pre-Prone = immediately prior to prone positioning, Prone 1 = following prone positioning, Prone 2 = the mid-point of prone positioning, Prone 3 = prior to supination, and Post-Prone = following supination. Statistical Analysis: Analyzed by repeated measures two-way ANOVA with Tukey’s post-hoc test for multiple comparisons for line graphs and Mann-Whitney U test for box plot. ****P<0.0001, ** P<0.01, * P<0.05. Patients with incomplete data sets were excluded from analysis. a–c: error bars represent standard deviation. d: box plot with bars representing range.