Table 2.
Weight outcomes at 52 weeks by short-term weight trajectory clusters
| Cluster 1: Minimal-to-no weight loss n = 132 |
Cluster 2: Delayed-minimal weight loss n = 141 |
Cluster 3: Steady-moderate weight loss n = 688 |
p-Value* | |
|---|---|---|---|---|
| Mean percent weight change from baseline (95% CI) | 0.4 (−0.5, 1.4) | −1.8 (−2.7. −0.9) | −5.1 (−5.6, −4.5) | <0.0001 |
| Unadjusted mean difference | ref | −2.2 (−3.5, −0.9) p = 0.001 |
−5.5 (−6.8, −4.2) p < 0.0001 |
|
| Adjusted mean difference | ref | −2.2 (−3.8, −0.6) p = 0.007 |
−5.5 (−6.7, −4.2) p < 0.0001 |
|
| ≥5% weight loss from baseline, n (%) | 13 (9.8) | 35 (24.8) | 278 (40.4) | <0.0001 |
| Unadjusted odds ratio | ref | 3.0 (1.5, 6.0) | 6.2 (3.4, 11.2) | |
| Adjusted odds ratio | ref | 3.0 (1.5, 6.0) p = 0.002 |
6.2 (3.4, 11.2) <0.0001 |
Unadjusted mean differences and unadjusted odds ratios with 95% confidence intervals (CIs) and p-values for cluster comparisons were derived from simple linear regression or logistic regression, respectively.
Adjusted mean differences and odds ratios with 95% CI and p-values for cluster comparisons were derived from multivariable linear regression or logistic regression, respectively, adjusting for patient demographics and clinical characteristics.
*p-Value derived from analysis of variance for bivariate comparisons of means by cluster and chi-square tests of independence for bivariate comparisons of categorical variables by cluster.