Table 3.

TP53 non-pathogenic variations identified in Polish early-onset breast cancers

Variant	Exon/Intron	Amino acid	rs number	Effect	Number of cases
c.74 + 38C > G	Intron 2	–	rs1642785	5′UTR variant	18
c.75-40G > A	Intron 2	–	rs372756865	5′UTR variant	1
c.75-48 T > C	Intron 2	–	rs1295353442	5′UTR variant	5
c.97-29C > A	Intron 3	–	rs17883323	Intronic	2
c.96 + 25ACCTGGAGGGCTGGGG	Intron 3	–	rs59758982	Intronic	26
c.97-29C > A	Intron 3	–	rs17883323	Intronic	2
c.560-40A > G	Intron 5	–	rs377059569	Intronic	1
c.618G > A	Exon 6	p.Leu206 =	rs142813240	Synonymous	3
c.639A > G	Exon 6	p.Arg213 =	rs 1,800,372	Synonymous	1
c.672 + 62A > G	Intron 6	–	rs1625895	Intronic	7
c.782 + 72C > T	Intron 7	–	rs12947788	Intronic	8
c.782 + 92 T > G	Intron 7	–	rs 12,951,053	Intronic	8
TP53_g.14032G > A	Exon 9	p. Lys320 =	–	Synonymous	2
c.993 + 12 T > C	Intron 9	–	rs1800899	Intronic	1
17:7673445G > T	Intron 9	–	–	Intronic	1
c.1077A > G	Exon 10	p. Pro359 =	rs539224556	Synonymous	1
c.1100 + 44C > T	Intron 10	–	rs905346274	Intronic	1
c.1100 + 30A > T	Intron 10	–	rs17880847	Intronic	3
c.1101-49C > T	Intron 10	–	rs17881850	Intronic	3