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. 2020 Nov 11;35(1):132–138. doi: 10.1007/s12149-020-01544-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Lymphoid organ metabolism and outcome of CAR-T-cell therapy. a Serial ¹⁸F-FDG PET/CT (upper row) showing metabolically active disease at baseline (PET1), partial remission at PET2, and progressive disease at PET3 (that is, unfavourable outcome). Marked early reduction of spleen activity, both in absolute quantification (SUV_mean) and relative to liver metabolism (lower row). b Marked early reduction in activity of lymphoid organs was associated with worse outcome (spleen signal, P = 0.0368; lymph node signal, P = 0.0470). c Low bone marrow signal and low activity of lymphoid organs early after CAR-T-cell therapy demonstrated a borderline significant association with poor outcome (P ≤ 0.0784). d Metabolic activity of lymphoma burden was higher in patients developing neurotoxicity (P = 0.0489)