Table 1.

Median values of thyroid indices prior to each cycle of treatment in controls and those who subsequently developed ipilimumab hypophysitis (IH)

	Cycle 1		Cycle 2		Cycle 3		Cycle 4
	Control	IH	Control	IH	Control	IH	Control	IH
TSH (mU/L)	1.490	1.375	1.455	1.160	1.360	0.4800	1.445	0.3400
T4 (pmol/L)	13.40	12.25	13.50	13.90	14.10	11.00***	13.85	10.70*
TSH Index	1.980	1.840	2.000	1.790	2.010	1.140***	2.015	0.6050*
sTSH Index	− 1.070	− 1.275	− 1.035	− 1.340	− 1.020	− 2.310***	− 1.015	− 3.100*
% Change in TSH			− 5.850	− 9.420	− 6.830	− 41.00	− 4.840	− 81.52

*P, 0.05 between controls and IH at that cycle

***P < 0.001