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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Graefes Arch Clin Exp Ophthalmol. 2020 Aug 20;259(1):93–100. doi: 10.1007/s00417-020-04884-5

Fig. 2. Decreased Retinal Vascular Permeability and expression of chemokine receptors in retinas of mice treated with TAK-779.

Fig. 2.

(A) A schematic representation of the design of the experiment. (B) Representative western blot image of Albumin and β-tubulin protein from the retinas of non-diabetic, diabetic (Vehicle) and diabetic (drug treated) STZ mice (Right). Albumin levels were significantly increased in the retinas of diabetic mice (Vehicle) in comparison with non-diabetic mice (*p=0.01), the drug treated diabetic animals had a significantly less amount of albumin in retinas in comparison with the untreated diabetic animals (**p=0.01) (Left). (C) The gene expression levels of both CCR2 and CCR5 receptors were significantly increased in the retinas of diabetic mice compared with non-diabetic mice (*p=0.03, *p=0.03), and were significantly decreased in the drug treated diabetic mice in comparison with vehicle treated diabetic animals (**p=0.02, **p=0.02). Data are mean ±S.D.