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. 2020 Dec 9;184(1):120–132.e14. doi: 10.1016/j.cell.2020.12.006

Figure 2.

Figure 2

Parallel Genome-wide CRISPR Screening against Multiple HCoVs Uncovers Host Factors and Pathways with Pan-CoV and Virus-Specific Functional Roles

(A) Bubble plot of data from HCoV-OC43 screens at 33°C. Red lines denote z = ±2.

(B) Bubble plot of data from HCoV-NL63 screens at 33°C. Red lines denote z = ±2.

(C) Bubble plot of data from HCoV-229E screens at 33°C. Red lines denote z = ±2.

(D) UpSet plot showing enriched hits overlapping in screens across all four viruses. Select genes for enriched sgRNAs are indicated.