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. 2020 Dec 9;184(1):120–132.e14. doi: 10.1016/j.cell.2020.12.006

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CoVs Co-opt an Extensive Network of Human Proteins and Pathways to Complete Their Life Cycles

(A) Network analysis of human CoV host factors for all significant screening hits using the STRING-db protein:protein interaction network. Nodes are subdivided by number of virus screens by color and size for which the node was significant. Highly interconnected and functionally related genes are further highlighted in gray.

(B–G) Comparative pathway-focused heatmaps showing enriched and depleted sgRNAs across all CRISPR screens.