Table 2.
Summary of clinical findings of Carney Complex (CNC) patients with and without cardiac myxoma, based on diagnostic criteria.
| CNC patients without cardiac myxoma (n=184, F=103, M=74, uncertain=7) | CNC patients with cardiac myxoma (n=136, F=78, M=58) | P-value | CNC patients with at least 1 recurrence (n=60, F=44, M=16) | P-value | |
|---|---|---|---|---|---|
| Lentigines (%) | 59 (32) | 88 (64.7) | 0.00008 | 36 (60) | 0.3 |
| Blue nevi (%) | 14 (7.6) | 14 (10.3) | 0.1 | 3 (5) | 0.06 |
| Cutaneous myxoma (%) | 28 (15.2) | 41 (30.1) | 0.01 | 19 (31.6) | 0.9 |
| Breast myxomatosis (%) | 10 (9.7) | 27 (34.6) | 0.008 | 16 (36.3) | 0.1 |
| Thyroid manifestationsa (%) | 15 (8.1) | 35 (25.7) | 0.001 | 20 (33.3) | 0.1 |
| LCCSCT or calcifications on testicular U/S (%) | 23 (31) | 29 (50) | 0.3 | 9 (56.3) | 0.09 |
| Pituitary adenoma (%) | 15 (8.1) | 28 (20.6) | 0.004 | 14 (23.3) | 0.1 |
| PMS (%) | 4 (2.1) | 16 (11.7) | 0.009 | 8 (13.3) | 0.5 |
| PPNAD (%) | 56 (30.4) | 57 (41.9) | 0.07 | 29 (48.3) | 0.2 |
LCCSCT: large cell calcifying sertoli cell tumor; PMS: Psammomatous melanotic schwannoma; PPNAD: primary pigmented nodular adrenocortical disease; u/s: ultrasound; F=female; M=male
Significance was set at <0.05
a
Includes: Thyroid carcinoma or multiple, hypoechoic nodules on thyroid ultrasonography