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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2020 Dec 14;200:173088. doi: 10.1016/j.pbb.2020.173088

TABLE 2:

Projection-specific role in opioid-seeking behaviors.

Projection Role References
PFC to NAc Expression of withdrawal-associated aversion. Zhu et al., 2016
PVT to NAc to LH Relapse to context-induced opioid-seeking. Keyes et al., 2020
vmPFC to NAc Context-induced opioid relapse. Bossert et al., 2012
LH orexinergic projections Motivation for opioid-seeking James et al., 2017

Abbreviations: Amy, Amygdala; BLA; Basolateral Amygdala; LH, Lateral Hypothalamus; NAc, Nucleus Accumbens; PVT, Paraventricular Nucleus of the Thalamus; PFC, Prefrontal Cortex; vmPFC, Ventro-medial PFC.