Table 1.
Multiple sequence alignment based on the PRKAR1B isoform NM_001164760.2
| Organism | Aminoacid Sequence | |||
|---|---|---|---|---|
| p.I40V | ||||
| variant sequence | ...YVQLHGIQQ VLKDCIVHLC | V | SKPER------------PMKFLRE---... | |
| Human | (Homo sapiens) | ...YVQLHGIQQ VLKDCIVHLC | I | SKPER------------PMKFLRE---... |
| Monkey | (Callithrix jacchus) | ...YVQLHGIQQVLKDCIVHLC | I | SKPER------------PMKFLRE---... |
| Rat | (Rattus norvegicus) | ...---------------------------QIMCV | V | SVCGEGMGWDPVEISQSHAE... |
| Chicken | (Gallus gallus) | ...YVQKHNIQQILKECIVNLC | I | AKPDR------------PMKFLRE---... |
| Frog | (Xenopus laevis) | ...YVQKYNIQQLLKECIVNLC | I | AKPDR------------PMKFLRE---... |
| Zebrafish | (Danio rerio) | ...FVQKHNIQQILKECIVNLC | I | AKPER------------PMKFLRE---... |
| p.A67V | ||||
| variant sequence | ...E------HFEKLEKEENRQIL | V | RQKSNSQSDSHDEEVSPTPP... | |
| Human | (Homo sapiens) | ...E------HFEKLEKEENRQIL | A | RQKSNSQSDSHDEEVSPTPP... |
| Monkey | (Callithrix jacchus) | ...E------HFEKLEKEENRQIL | A | RQKSNSQSDSHDEEVSPTPP... |
| Rat | (Rattus norvegicus) | ...SHAEGCAQTTGLEENRQIL | A | RQKSNSQCDSHDEEISPTPP... |
| Chicken | (Gallus gallus) | ...E------HFEKLEKEECKQIL | A | RQKSSSQSDSHDDEISPPPP... |
| Frog | (Xenopus laevis) | ...E------HFEKLEKEECKQIL | A | QQKSNSQSDSHDDEISPPPP... |
| Zebrafish | (Danio rerio) | ...E------HFEKLEKEECKQIM | A | RQKSNSQSDSHDDEVSPPPP... |
| p.A300T | ||||
| variant sequence | ...KIVVQGEPGDDFYIITEGT | T | SVLQRRSPNEEYVEVGRLGP... | |
| Human | (Homo sapiens) | ...KIVVQGEPGDDFYIITEGT | A | SVLQRRSPNEEYVEVGRLGP... |
| Monkey | (Callithrix jacchus) | ...KIVVQGEPGDDFYIITEGT | A | SVLQRRSPNEEYVEVGRLGP... |
| Rat | (Rattus norvegicus) | ...KIVVQGEPGDDFYIITEGT | A | SVLQRRSPNEEYVEVGRLGP... |
| Chicken | (Gallus gallus) | ...KIVVQGEPGDDFFIITEGT | A | SVLQRRSDNEEYVEVGRLGP... |
| Frog | (Xenopus laevis) | ...KIVVQGEPGDDFFIITEGT | A | SVLQRRSDNEEYVEVGRLGP... |
| Zebrafish | (Danio rerio) | ...KIVVQGEPGDDFFIITEGT | A | SVLQRRSDNEEYVEVGRLGP... |