Skip to main content
. 2020 Dec 9;49(1):53–66. doi: 10.1093/nar/gkaa1137

Figure 5.

Figure 5.

DeepFun captures tissue specific, functional SNPs. (A) The average absolute SAD values of DNA accessibility chromatin features for the most associated SNP (rs886037620) with ulcerative colitis (UC) (only tissues with at least eight replicates profiles were presented). (B) The SAD values of schizophrenia-associated SNPs (max SAD > 0.1) over different DNA accessibility profiles. (C) Canonical correspondence analysis (CCA) (details in methods) of schizophrenia-associated variants SAD scores across different DNase-seq chromatin profiles. As functional variants impact of SAD and source of each DNase-seq profiles (tissue) are assumed to be of unit variance, their projections on the plane reside within a circle of radius 1 centered at the origin. Distance to the center indicates the strength of the association. For clarity, one circle with radius of 0.5 is shown to indicate associations of variants and tissues. Variants (dots) located within or outside of circle with radius of 0.5 were labeled in green and red color, respectively. Different tissue profiles located within or outside of circle with radius of 0.5 were labeled in orange color text or marked as triangle.