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. 2020 Dec 11;49(1):269–284. doi: 10.1093/nar/gkaa1162

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — TonEBP resolves R-loops. (A and B) Cells transfected with siRNA as indicated were irradiated with UV (60 J/m²) and analyzed at 2 or 15 min after UV-irradiation. R loop and nucleoli were visualized by immunostaining (A). R-loop foci per nucleus were counted from >80 nuclei in three independent experiments (B). Mean ± SD, *P < 0.01. Mean values are shown as numbers. (C and D) siRNA-transfected cells were either untreated (no CPT) or treated with 10 μM CPT for 3 h and analyzed immediately or after 3 h further incubation in fresh media without CPT.