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. 2020 Dec 17;49(1):584–594. doi: 10.1093/nar/gkaa1199

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — AcrIF4, AcrIF7 and AcrIF14 bind different sites of the Csy complex for its inhibition. (A) Binding sites of AcrIF4, AcrIF7 and AcrIF14 on the Csy complex. AcrIF4, AcrIF7 and AcrIF14 are shown in surface representation, whereas the Csy complex is in cartoon representation. (B) Side-by-side comparison of AcrIF proteins that bind to the DNA vise of Cas8f, including AcrIF2, AcrIF6, AcrIF7 and AcrIF10. (C) Side-by-side comparison of AcrIF proteins that bind to the thumb domains of Cas7.4f and Cas7.6f, including AcrIF1, AcrIF9 and AcrIF14.