Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 4;49(1):1–14. doi: 10.1093/nar/gkaa1112

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 5. — Correlative backscattered electron (BSE) and NanoSIMS images of mouse tissues following treatment with Br-ASO. A wild-type mouse was given a subcutaneous injection of Br-ASO (32 mg/kg). After 72 h, tissues were harvested and processed for BSE and NanoSIMS imaging. ³²S NanoSIMS images were useful for visualizing morphology; bromine images (⁷⁹Br + ⁸¹Br) and composite bromine (green) + ³¹P (red) + ³²S (blue) NanoSIMS images were created to show the distribution of Br-ASO in the liver, heart, and kidney. Arrows point to endolysosomes. Mito, mitochondria; Golgi, Golgi apparatus; ER, endoplasmic reticulum. Scale bars, 4 μm.