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. 2020 Dec 4;49(1):1–14. doi: 10.1093/nar/gkaa1112

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — NanoSIMS images of the same kidney section shown in Figure 4, revealing the distribution of Br-ASO in the kidney. Shown here are ³¹P, ³²S, ⁷⁹Br, and composite ³¹P (red) + ³²S (blue) + ⁷⁹Br (green) NanoSIMS images of kidney from a mouse that had been injected subcutaneously with Br-ASO. Images show localized areas of Br-ASO enrichment (endolysosomes) in renal tubule cells. Scale bars, 20 μm.