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Evolutionary origin of the AcNEIL1 acetylation center. (A) Phylogenetic tree of invertebrate species with (red) and without (black) human NEIL1 gene homologs, as assessed by blastp. (B) Sequence conservation at the acetylation center in NEIL1 C-ter flexible region. Black, >93% sequence homology among 241 species; blue, highly conserved lineage-specific amino acids; red, conserved Lys residues carrying the acetylation mark in human NEIL1.
