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. 2020 Nov 10;49(1):e1. doi: 10.1093/nar/gkaa1014

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Validation of TENET-inferred GRNs for the mouse embryonic stem cell (mESC) pluripotency. (A) A tSNE plot of the mESCs (2iL and SL) and NPCs shows distinct expression. (B) The c-Myc target genes have higher TE values than the randomly selected 541 genes (repeated 1000 times). The expression ratio of predicted Tbx3 (C) or Esrrb (D) target genes (Tbx3 or Esrrb overexpression (Tbx3+ or Esrrb+) against control (Tbx3- or Esrrb-)). The expression ratio of predicted Pou5f1 (E) or Nanog (F) target genes (knockdown versus wild-type).