Figure 3.

TENET outperformed other tools when predicting key regulatory factors for mESC pluripotency and direct reprogramming from mouse fibroblast into cardiomyocyte. (A) Key regulatory factors for mESC pluripotency and neural differentiation predicted by TENET. The purple bar denotes pluripotency and neural differentiation genes. (B) ROC curves and (C) Area Under Precision-Recall Curves (AUPRCs) for the prediction of key regulatory factors of pluripotency and neural differentiation. (D) Key regulatory factors for direct reprogramming into cardiomyocyte in the TENET-inferred GRN. Three major reprogramming factors Mef2c, Tbx5 and Gata4 have a large number of targets. (E) ROC curves and (F) AUPRCs for the prediction of key regulatory factors of cardiomyocyte.