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. 2020 Dec 10;49(1):432–443. doi: 10.1093/nar/gkaa1178

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Proposed model for global and gene-specific regulation by Pus6 and MetRS. Pus6 modifies uridines to pseudouridines on both elongator tRNA^Met and target mRNAs (e.g. YEF3). These modifications enhance MetRS binding on both types of RNA. MetRS binding to tRNA^Met presumably affects its charging and thereby has a global impact on translation, while MetRS binding to an mRNA leads to a gene-specific impact.