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Doxorubicin-induced cardiotoxicity can be attenuated by MMP inhibitors. Doxorubicin (DOX) increases in MMP-2 and NTT-MMP-2 activity, which leads to cardiac dysfunction, fibrosis, titin proteolysis, and eventually heart failure. Inhibition of MMP-2 and NTT-MMP-2 expression with doxycycline or ONO-4817, prevents DOX induced cardiac toxicity and heart failure.
