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. 2019 Dec 10;117(1):178–187. doi: 10.1093/cvr/cvz331

Figure 2.

Figure 2

Cardiac dimensions and function in Nox4−/− mice and WT littermates after volume overload. (A) Representative LV echocardiographic M-mode images after Shunt compared to Sham control; scale bar in mm on the right, time stamp in seconds at the bottom. (B–I) Mean data of LV end-diastolic volume (LVEDV) (B), end-systolic volume (LVESV) (C), stroke volume (D), septal thickness (E), posterior wall (PW) thickness (F), relative wall thickness (G), ejection fraction (EF) (H), and heart rate (I) after Shunt compared to Sham (n = 9–12/group). *P < 0.05, **P < 0.01 for Shunt vs. respective Sham controls, ‡P < 0.05 significant interaction between genotypes, #P < 0.01 between Shunt groups and significant interaction (P < 0.01) between genotypes, n.s., not significant between genotypes using two-way ANOVA followed by Bonferroni post-hoc test for multiple comparisons.