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. 2019 Dec 10;117(1):178–187. doi: 10.1093/cvr/cvz331

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© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cardiac gene expression, fibrosis, and capillary density in Nox4^−/− mice and WT littermates after volume overload. (A) LV mRNA levels of ANP (atrial natriuretic peptide), BNP (brain natriuretic peptide), α-skeletal actin, and SERCA-2α (sarcoplasmic/endoplasmic reticulum calcium ATPase-2α) after Shunt or Sham control. (B and C) Representative images and mean data of Picrosirius red-stained sections indicating fibrotic regions (B) and isolectin B4-staining depicting cardiac capillaries (C) after Shunt or Sham (n = 5–7/group). *P < 0.05, **P < 0.01 in Shunt vs. Sham, n.s., not significant between genotypes using two-way ANOVA followed by Bonferroni post-hoc test for multiple comparisons.