Figure 1.

Cardiac function and morphology in control (C) and DXR-administered mice treated with MMP inhibitors Doxy or ONO-4817 (ONO). (A–D) DXR impaired both systolic and diastolic function and reduced cardiac output. Doxy and ONO rescued DXR-reduced fractional shortening and ejection fraction. (E–H) DXR caused adverse cardiac remodelling marked by the thinning of the posterior wall and interventricular septum and expansion of the left ventricle end-systole, which were attenuated by Doxy. n = 10 mice per group. *P < 0.05 by one-way ANOVA followed by the Sidak’s post hoc test.