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MMP-2 levels and activity in the ventricle and plasma from DXR mice treated with MMP inhibitors. (A and B) DXR increased MMP-2 protein levels (n = 8) and activity (n = 10) in the heart, which were prevented by Doxy or ONO. (C and D) The plasma from DXR-treated mice exhibited increased levels of MMP-2 protein (n = 7–8) and activity (n = 9–10), which were reduced by ONO. *P < 0.05 by one-way ANOVA followed by the Sidak’s post hoc test.
