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. 2020 Feb 17;117(1):188–200. doi: 10.1093/cvr/cvaa017

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.

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Transmission electron micrographs of cardiac myocytes from left ventricular sections of control- and DXR-treated mice. (A) Control hearts exhibit normal myofilament morphology. (B) The myocardium of DXR mice exhibits extensive myofilament disorganization, diffuse Z-discs (Z), and disassembly of M-line (M), shown by black arrows, compared to control. (C and D) Doxy or ONO protected against DXR-induced sarcomeric damage in the heart. (E and F) DXR hearts exhibit mitochondrial degeneration (white arrows) and increased glycogen particles (arrowheads) compared to control. (G and H) Doxy or ONO hearts exhibited similar mitochondrial morphology to control. Representative of more than 50 images captured from 4 hearts from each group. Scale bar = 500 nm.