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DXR-induced effects on MMP-2 in hESC-CMs. (A) MMP-2 protein levels were elevated in lysates from hESC-CM treated with DXR (1 µM, 24 h, n = 4). (B) DXR did not affect MMP-2 activity in hESC-CM lysates (n = 4). (C) Secreted MMP-2 protein levels and (D) activity were elevated in the conditioned media of DXR-treated hESC-CM (n = 4). Elevated MMP-2 activity in the conditioned media was blocked by ONO. *P < 0.05 by one-way ANOVA followed by the Sidak’s post hoc test.
