2. Major toxicities and complications in gastric cancer patients with peritoneal metastasis.

Adverse event	HIPEC-chemotherapy (n=249) [n (%)]					Chemotherapy alone (n=249) [n (%)]				P
	Untested	Grade 1−2	Grade 3	Grade 4		Untested	Grade 1−2	Grade 3	Grade 4
*, Electrolyte disturbances include hypokalemia, hyperkalemia, hyponatremia, hypernatremia, hypomagnesemia, hypophosphatemia and hypercalcemia; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HIPEC, hyperthermic intraperitoneal chemotherapy.
Hypoalbuminemia	2 (0.8)	208 (84.2)	7 (2.8)	0 (0)		25 (10.0)	119 (53.1)	1 (0.4)	0 (0)	<0.001
Anemia	0 (0)	176 (70.7)	24 (9.6)	0 (0)		5 (2.0)	143 (58.6)	28 (11.5)	1 (0.4)	0.018
Lymphopenia	2 (0.8)	141 (57.1)	47 (19.0)	5 (2.0)		5 (2.0)	70 (28.7)	18 (7.4)	5 (2.0)	<0.001
Electrolyte disturbances*	0 (0)	133 (53.4)	13 (5.2)	1 (0.4)		15 (6.0)	82 (35.0)	14 (6.0)	2 (0.9)	0.001
Fever	0 (0)	107 (43.0)	4 (1.6)	0 (0)		0 (0)	41 (16.5)	1 (0.4)	0 (0)	<0.001
Abdominal pain	0 (0)	88 (35.3)	14 (5.6)	0 (0)		0 (0)	39 (15.7)	3 (1.2)	0 (0)	<0.001
Abdominal bloating	0 (0)	44 (17.7)	2 (0.8)	0 (0)		0 (0)	43 (17.3)	4 (1.6)	0 (0)	0.707
Nausea	0 (0)	71 (28.5)	1 (0.4)	0 (0)		0 (0)	117 (47.0)	1 (0.4)	0 (0)	<0.001
Vomiting	0 (0)	64 (25.7)	2 (0.8)	0 (0)		0 (0)	96 (38.6)	1 (0.4)	0 (0)	0.008
AST increased	2 (0.8)	52 (21.1)	4 (1.6)	0 (0)		15 (6.0)	46 (19.7)	1 (0.4)	0 (0)	0.370
ALT increased	2 (0.8)	39 (15.8)	5 (2.0)	0 (0)		15 (6.0)	47 (20.1)	1 (0.4)	0 (0)	0.132
Pneumonia	0 (0)	33 (13.3)	4 (1.6)	1 (0.4)		0 (0)	20 (8.0)	2 (0.8)	0 (0)	0.098
Leukopenia	2 (0.8)	24 (9.7)	2 (0.8)	1 (0.4)		5 (2.0)	37 (15.2)	12 (4.9)	7 (2.9)	<0.001
Fatigue	0 (0)	24 (9.6)	0 (0)	0 (0)		0 (0)	38 (15.3)	1 (0.4)	0 (0)	0.058
Thrombocytopenia	2 (0.8)	22 (8.9)	4 (1.6)	1 (0.4)		5 (2.0)	21 (8.6)	3 (1.2)	3 (1.2)	0.749
Neutropenia	2 (0.8)	19 (7.7)	3 (1.2)	1 (0.4)		5 (2.0)	41 (16.8)	7 (2.9)	13 (5.3)	<0.001
Creatinine increased	1 (0.4)	13 (5.2)	0 (0)	0 (0)		14 (5.6)	10 (4.3)	0 (0)	0 (0)	0.611
Ileus	0 (0)	12 (4.8)	2 (0.8)	0 (0)		0 (0)	8 (3.2)	2 (0.8)	1 (0.4)	0.810
Diarrhea	0 (0)	10 (4.0)	0 (0)	0 (0)		0 (0)	10 (4.0)	1 (0.4)	0 (0)	0.999
Adhesions	0 (0)	2 (0.8)	1 (0.4)	0 (0)		0 (0)	0 (0)	1 (0.4)	0 (0)	0.749
Rash maculopapular	0 (0)	2 (0.8)	0 (0)	0 (0)		0 (0)	1 (0.4)	0 (0)	0 (0)	0.999
Hemorrhage	0 (0)	1 (0.4)	0 (0)	0 (0)		0 (0)	3 (1.2)	0 (0)	0 (0)	0.616
Dyspnea	0 (0)	1 (0.4)	0 (0)	0 (0)		0 (0)	2 (0.8)	2 (0.8)	0 (0)	0.209
Gastroplegia	0 (0)	0 (0)	0 (0)	0 (0)		0 (0)	2 (0.8)	0 (0)	0 (0)	0.499
Abdominal infection	0 (0)	0 (0)	7 (2.8)	1 (0.4)		0 (0)	0 (0)	3 (1.2)	0 (0)	0.221
Thromboembolism	0 (0)	0 (0)	0 (0)	1 (0.4)		0 (0)	1 (0.4)	0 (0)	0 (0)	0.999
Peripheral neuritis	0 (0)	0 (0)	0 (0)	0 (0)		0 (0)	3 (1.2)	0 (0)	0 (0)	0.098