2. Structure and OR of oral microbiome-based prediction model for risk of malignant esophageal lesions in Anyang, China, 2006−2017.

Predictive species*	n (%)**			OR (95% CI)***
	Cases (N=84)	Controls (N=168)		Univariate	Multivariate
OR, odds ratio; 95% CI, 95% confidence interval; Ref., reference category; SDA, severe dysplasia and above. *, The optimal cut-off point for relative abundance of each predictive species was listed in the brackets; **, The analyzed dataset (full averaged dataset) contained a total of 84 SDA cases providing 143 oral specimens and 168 matched controls providing 285 oral specimens. For all specimens produced by each subject, bacterial abundance at the species level was averaged to produce a single value for that subject; ***, OR and 95% CI were derived by univariate conditional logistic regression analysis and multivariate conditional logistic regression analysis including all species listed in the Table as well as family history of esophageal cancer.
Actinomyces odontolyticus
Low carriage [<90% quantile (0.3677%)]	65 (77.4)	151 (89.9)		Ref.	Ref.
High carriage [≥90% quantile (0.3677%)]	19 (22.6)	17 (10.1)		2.58 (1.25−5.29)	2.16 (0.80−5.88)
Actinomyces viscosus
Low carriage [<95% quantile (1.5110%)]	72 (85.7)	159 (94.6)		Ref.	Ref.
High carriage [≥95% quantile (1.5110%)]	12 (14.3)	9 (5.4)		3.74 (1.29−10.89)	7.70 (1.75−33.87)
Dialister invisus
Low carriage [<75% quantile (0.0655%)]	49 (58.3)	126 (75.0)		Ref.	Ref.
High carriage [≥75% quantile (0.0655%)]	35 (41.7)	42 (25.0)		2.43 (1.31−4.51)	2.32 (1.02−5.30)
Fusobacterium mortiferum
Low carriage [<80% quantile (0.0016%)]	58 (69.0)	134 (79.8)		Ref.	Ref.
High carriage [≥80% quantile (0.0016%)]	26 (31.0)	34 (20.2)		1.94 (1.01−3.71)	4.64 (1.73−12.50)
Fusobacterium nucleatum
Low carriage [<30% quantile (0.5956%)]	9 (10.7)	51 (30,4)		Ref.	Ref.
High carriage [≥30% quantile (0.5956%)]	75 (89.3)	117 (69.6)		5.64 (2.13−14.88)	3.85 (1.12−13.24)
Lachnoanaerobaculum umeaense
Low carriage [< 95% quantile (0.4933%)]	67 (79.8)	159 (94.6)		Ref.	Ref.
High carriage [≥95% quantile (0.4933%)]	17 (20.2)	9 (5.4)		6.75 (2.24−20.41)	10.93 (2.24−53.38)
Leptotrichia hofstadii
Low carriage [<35% quantile (0.0782%)]	11 (13,1)	59 (35.1)		Ref.	Ref.
High carriage [≥35% quantile (0.0782%)]	73 (86.9)	109 (64.9)		3.65 (1.77−7.50)	2.36 (0.89−6.25)
Prevotella baroniae
Low carriage [<60% quantile (0.0051%)]	37 (44.0)	101 (60.1)		Ref.	Ref.
High carriage [≥60% quantile (0.0051%)]	47 (56.0)	67 (39.9)		2.15 (1.19−3.89)	1.98 (0.86−4.58)
Prevotella melaninogenica
Low carriage [<30% quantile (0.1074%)]	10 (11.9)	51 (30.4)		Ref.	Ref.
High carriage [≥30% quantile (0.1074%)]	74 (88.1)	117 (69.6)		4.79 (1.94−11.87)	3.26 (1.05−10.19)
Prevotella shahii
Low carriage [<90% quantile (0.0446%)]	62 (73.8)	151 (89.9)		Ref.	Ref.
High carriage [≥90% quantile (0.0446%)]	22 (26.2)	17 (10.1)		3.54 (1.65−7.63)	2.37 (0.81−6.90)
Rothia dentocariosa
Low carriage [<70% quantile (0.1806%)]	47 (56.0)	117 (69.6)		Ref.	Ref.
High carriage [≥70% quantile (0.1806%)]	37 (44.0)	51 (30.4)		2.04 (1.11−3.75)	2.66 (1.12−6.31)