S3. Species with differential abundance in cases of malignant esophageal lesions and controls based on DESeq analysis in Anyang, China, 2006−2017.
| Species* | baseMean** | log2 (fold change)±SE | P*** | Q**** |
| FDR, false discovery rate; SDA, severe dysplasia and above; SE, standard error. *, A total of 84 SDA cases providing 143 oral specimens and 168 matched controls providing 285 oral specimens were included in this analysis. For all specimens produced by each subject, bacterial abundance at each taxonomic level were averaged to produce a single value for that subject. All named and cultured species with a FDR-adjusted Q<0.10 are included in the Table; **, “baseMean” is the average of normalized count values, dividing by DESeq size factors, taken over all samples; ***, P values were obtained by using differential gene expression analysis based on the negative binomial distribution (DESeq) in the DESeq2 package, adjusting for education level, type of employment, cigarette smoking, alcohol consumption, and family history of esophageal cancer; ****, FDR-adjusted P value, the FDR adjustment was conducted at the species level. | ||||
| Actinomyces naeslundii | 278.57 | 0.75±0.21 | <0.001 | 0.006 |
| Actinomyces odontolyticus | 149.37 | 0.40±0.17 | 0.022 | 0.100 |
| Actinomyces radicidentis | 31.02 | 0.58±0.21 | 0.007 | 0.049 |
| Actinomyces viscosus | 336.96 | 0.59±0.19 | 0.002 | 0.022 |
| Alloprevotella rava | 20.51 | 0.57±0.21 | 0.006 | 0.048 |
| Alloprevotella tannerae | 32.72 | 0.50±0.20 | 0.011 | 0.061 |
| Bosea robiniae | 111.12 | −0.66±0.23 | 0.004 | 0.037 |
| Campylobacter concisus | 101.78 | 0.70±0.19 | <0.001 | 0.005 |
| Caulobacter vibrioides | 697.47 | −0.55±0.24 | 0.022 | 0.100 |
| Corynebacterium durum | 42.36 | 0.57±0.21 | 0.007 | 0.049 |
| Corynebacterium matruchotii | 303.41 | 0.91±0.22 | <0.001 | 0.001 |
| Dialister invisus | 73.40 | 0.79±0.22 | <0.001 | 0.006 |
| Fusobacterium mortiferum | 24.39 | 0.64±0.24 | 0.009 | 0.057 |
| Fusobacterium nucleatum | 1,358.57 | 0.53±0.16 | 0.001 | 0.015 |
| Fusobacterium simiae | 278.13 | 0.91±0.26 | 0.001 | 0.009 |
| Lachnoanaerobaculum umeaense | 151.14 | 0.54±0.17 | 0.001 | 0.015 |
| Leptotrichia buccalis | 693.34 | 0.82±0.23 | <0.001 | 0.005 |
| Leptotrichia hofstadii | 297.77 | 0.93±0.22 | <0.001 | 0.001 |
| Leptotrichia hongkongensis | 381.05 | 0.71±0.22 | 0.001 | 0.013 |
| Leptotrichia shahii | 50.77 | 0.53±0.22 | 0.015 | 0.082 |
| Neisseria flavescens|subflava | 722.49 | 0.49±0.21 | 0.020 | 0.099 |
| Prevotella baroniae | 13.11 | 0.74±0.22 | 0.001 | 0.008 |
| Prevotella intermedia | 227.10 | 0.54±0.23 | 0.022 | 0.100 |
| Prevotella maculosa | 27.34 | 0.45±0.19 | 0.020 | 0.099 |
| Prevotella melaninogenica | 699.20 | 0.49±0.21 | 0.021 | 0.099 |
| Prevotella micans | 12.19 | 0.87±0.22 | <0.001 | 0.003 |
| Prevotella oulorum | 58.03 | 0.50±0.22 | 0.023 | 0.100 |
| Prevotella pallens | 133.88 | 0.54±0.22 | 0.014 | 0.076 |
| Prevotella saccharolytica | 24.58 | 0.78±0.21 | <0.001 | 0.005 |
| Prevotella shahii | 16.42 | 0.77±0.19 | <0.001 | 0.001 |
| Pseudomonas toyotomiensis | 34.37 | −0.59±0.23 | 0.010 | 0.061 |
| Pseudopropionibacterium propionicum | 136.13 | 0.59±0.23 | 0.011 | 0.061 |
| Rothia dentocariosa | 164.18 | 0.59±0.21 | 0.005 | 0.040 |
| Selenomonas dianae | 21.72 | 0.60±0.21 | 0.005 | 0.040 |
| Selenomonas sputigena | 62.57 | 0.46±0.20 | 0.022 | 0.100 |
| Treponema socranskii | 58.19 | 0.73±0.22 | 0.001 | 0.013 |
| Treponema vincentii | 44.34 | 0.61±0.23 | 0.008 | 0.053 |