Table 1.
Clinical characteristics and echocardiographic parameters in female patients corrected for TOF grouped by parity
| TOF n=80 |
TOF without children (n=25) |
TOF with children (n=55) |
P value | OR (95% CI) |
P value | |
| Age, years | 37±10 | 30±9 | 40±9 | <0.01 | ||
| Height, cm | 165±7 | 165±7 | 165±7 | 0.96 | ||
| Weight, kg | 68±13 | 67±11 | 69±13 | 0.53 | ||
| HR, bpm | 69±13 | 73±10 | 67±13 | 0.07 | ||
| Transannular patch (%) | 30 (37) | 11 (44) | 19 (36) | 0.53 | ||
| SBP, mm Hg | 116±11 | 115±9 | 117±12 | 0.59 | ||
| DBP, mm Hg | 71±10 | 72±8 | 70±11 | 0.50 | ||
| QTc duration, ms | 460±31 | 460±29 | 460±32 | 0.96 | ||
| Exercise capacity, W | 131±27 | 127±24 | 132±28 | 0.53 | ||
| NYHA class | 1 (1–3) | 1 (1–3) | 1 (1–3) | 0.11 | ||
| NT-ProBNP, ng/L | 174 (30–836) | 110 (30–372) | 198 (49–836) | 0.11 | ||
| QRS duration, ms | 132 (82–174) | 124 (86–162) | 134 (82–174) | 0.62 | ||
| RV EDV, mL | 21.7±4.6 | 20.5±4.8 | 21.9±4.0 | 0.18 | ||
| RV ESV, mL | 11.3±2.9 | 10.8±2.9 | 11.3±2.7 | 0.52 | ||
| RV FAC, % | 47.8±7.2 | 47.1±7.4 | 48.1±7.3 | 0.58 | ||
| RV D3, cm | 7.3±0.7 | 7.1±0.7 | 7.4±0.7 | 0.03 | 2.1 (1.1 to 4.3) | 0.04 |
| PV vel, m/s | 1.9±0.6 | 1.9±0.7 | 1.9±0.5 | 0.91 | ||
| Mod-sev PV reg | 14 (17%) | 5 (22%) | 9 (16%) | 0.48 | ||
| LV MD, ms | 43.3±14 | 41.4±10 | 45.3±10 | 0.4 | ||
| LV GLS, % | −18.9±3.3 | −19.2±3.1 | −17.5±3.6 | 0.1 | ||
| RV MD, ms | 42±13 | 38±12 | 43±14 | 0.1 | ||
| RV GLS, % | −19.1±4.1 | −19.7±4.1 | −18.3±4.1 | 0.28 | ||
| RVOT, cm |
2.9±0.5 | 2.9±0.4 | 3.1±0.6 | 0.31 | ||
| LVEF, % | 55±8 | 56±8 | 54±8 | 0.39 |
Data are presented as mean±SD or median with range, as appropriate; p value from Student’s t-test, Mann-Whitney U or χ2 test as appropriate, and multivariable logistic regression adjusted for age.
DBP, diastolic blood pressure; EDV, end-diastolic volume; ESS, end-systolic strain; ESV, end-systolic volume; GLS, global longitudinal strain; HR, heart rate; LV, left ventricular; LVEF, left ventricular ejection fraction; MD, mechanical dispersion; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association classification; PV, pulmonary valve; RV, right ventricular; RV D3, right ventricular longitudinal diameter; RV FAC, right ventricular fractional area change; RVOT, right ventricular outflow tract; SBP, systolic blood pressure; TOF, tetralogy of Fallot; VA, ventricular arrhythmia.